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In the short term trials, one out of every ten patients experienced severe reactions. In one week trial, at least one in six patients was severely affected. Cymbalta withdrawal effects , including extreme mood swings anger, irritability , debilitating brain zaps, and physical and neurological problems, can be severe and extend for weeks and even months.
When this happens, your doctor may ask you to go back on the medication and taper more slowly. This can help reduce your side effects and make them more manageable. If you have already started to taper off of Cymbalta or are planning to do so in the future, here are some suggestions for how to wean off Cymbalta successfully:. When you stop taking Cymbalta or any other antidepressant, you may experience withdrawal side effects. For this reason, Cymbalta should never be stopped or tapered off without supervision by a medical professional.
If you do experience side effects during this process, just remember that these symptoms are a temporary response to a change in your brain chemistry.
Cymbalta is a powerful medication, and it can have a serious effect on the body when it interacts with other drugs and alcohol. On their own, alcohol…. Cymbalta duloxetine is approved by the Food and Drug Administration for the management of fibromyalgia in adults. Side effects include blurred…. An SNRI, or a serotonin-norepinephrine reuptake inhibitor, works by inhibiting the reabsorption of two important brain chemicals. See how this type of…. If you're wondering about your options for AFib medications, consult our explanatory list of AFib drugs to help yourself control your condition.
This risk is increased in those with substantial alcohol use or chronic liver disease. Orthostatic hypotension, or a drop in blood pressure when standing or getting up from sleeping, has been reported in patients taking duloxetine. The risk may be greater in patients also taking medications for high blood pressure. Increased heart rate, irregular menstrual cycle, increased frequency of urination or difficulty urinating, increased liver enzymes, teeth grinding, low sodium symptoms of low sodium levels may include headache, weakness, difficulty concentrating and remembering , angle closure glaucoma symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye , serotonin syndrome symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death , hypertensive crisis severely elevated blood pressure , myocardial infarction heart attack , Stevens-Johnson Syndrome rash , pancreatitis SNRI antidepressants, including duloxetine, may increase the risk of bleeding events.
Combined use of aspirin, nonsteroidal anti-inflammatory drugs e. This may include gums that bleed more easily, nose bleed, or gastrointestinal bleeding. Some cases have been life threatening. To date, there are no known problems associated with long term use of duloxetine.
It is a safe and effective medication when used as directed. Duloxetine should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors MAOIs. Sleep, energy, or appetite may show some improvement within the first weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to weeks to fully improve.
Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. In short-term studies, antidepressants increased the risk of suicidality in children, adolescents, and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults age 65 and older taking antidepressants have a decreased risk of suicidality.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. All patients being treated with antidepressants for any indication should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment. Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists.
This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions.
To help make it easier to come off Cymbalta, your doctor will likely recommend a taper lasting at least two weeks. Tapering a medication means working with your doctor to develop a plan to take progressively smaller doses of a drug over an extended period of time.
It is unclear whether or not a slow Cymbalta taper will always prevent withdrawal symptoms, but it is generally considered the safest way to stop an antidepressant. Work with your doctor to develop a tapering schedule that fits your needs.
Your doctor may want to switch you to a different antidepressant or provide medical support for your withdrawal symptoms. Other ways to ease the withdrawal experience include:. Although quitting Cymbalta cold turkey is rarely dangerous, it is best to consult your doctor before attempting to do so. Tell your doctor why you are interested in quitting and ask about tapering options. After Cymbalta, you may require ongoing treatment. The nature of that treatment will depend on a variety of factors, including the state of your mental health and your reasons for stopping the medication.
Unlike other medications, like antibiotics, that work for almost everyone, antidepressants can be really hit-or-miss. A medication that your friend calls a lifesaver, might make you too dizzy to play with your kids or too foggy to work. Brain chemistry is an incredibly complex system involving not only neurotransmitters like serotonin, but also nerve cells, genes, and brain structures. If it were as easy as turning up the dial on one neurotransmitter and turning down the dial on another, depression would be much easier to treat.
Treating depression can involve a process of trial and error. Depression is a disease with a very high reoccurrence rate. If you have had one or more episodes of severe depression, you may be a good candidate for maintenance therapy. Typically, this means continuing with a therapeutic dose of antidepressants to reduce the risk of relapse.
Other forms of maintenance therapy include psychotherapy. You can also call them at HELP If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at for support and assistance from a trained counselor.
If you or a loved one are in immediate danger, call
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